A recent report suggests that treatment with a combination of two commonly used anti-cancer drugs, doxorubicin and zoledronic acid, may benefit women with breast cancer. Doxorubicin is an anthracycline antibiotic that is widely used in cancer chemotherapy. It is thought to work by intercalating DNA and preventing cell replication.
Zoledronic acid is a third generation bisphosphonate that is used to prevent fractures in cancer patients with bone metastases. The bone destruction associated with malignancy develops because tumor cells synthesize and release soluble factors that stimulate osteoclasts to resorb bone. The bisphosphonate drugs act by inhibiting osteoclast function.
Zoledronic acid and other bisphosphonates are also used to treat osteoporosis – a single dose of zoledronic acid has been shown to increase bone mineral density for up to a year.
The new study looked at the effects of the two drugs given alone, sequentially , or in combination on the growth of established breast tumours in mice. Alone out of the treatment methods, doxorubicin followed 24 hours later by zoledronic acid almost completely abolished tumor growth in the absence of bone disease. Zoledronic acid has already been shown to reduce the risks of fractures in breast cancer patients with bone metastases and the new study provides hope that new dosing regimens may provide additional benefits.
There are common signs or symptoms of breast cancer :
1. The most obvious sign of this ailment is a lump in the breast or armpit. A self-examination test, once a month, or a visit to the doctor can expose any lump in this area.
2. Change in the size of the breast & shape. If you notice any unusual changes in its shape or size, do not ignore it.
3. There is nipple inversion & spontaneous single nipple discharge. If you observe that your nipples are turning inwards, this may be an indication that everything is not working as well.
4. Pain in the breast is not a reliable symptom but can also be indicative of other breast problems.
One way that helps patients to get rid of pains and side effects is that going for alternative cancer treatments. Alternative cancer treatment helps one to cope with symptoms caused by cancer.
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Treatments For Cancer