The bacterium responsible for tuberculosis (TB), mycobacterium tuberculosis (Mtb), is notoriously difficult to kill. The most commonly used antibiotics, rifampicin and isoniazid, need to be used for extended periods of time (typically 6-24 months) to effectively eliminate infection. In addition,…
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Targeting the MTB Proteasome
The ability of Mycobacterium tuberculosis (MTB) to establish latent infection poses significant problems in the treatment of TB, but a team of scientists led by researchers at Weill Cornell Medical College have now discovered compounds that are able to kill…
Mycobacterium tuberculosis NAD+ Synthetase Characterised
The World Health Organisation estimates that one third of the world’s population is latently infected with Mycobacterium tuberculosis (MTB), and that ten per cent of infected individuals will develop active disease. Current treatments for tuberculosis are effective only during active…
TB confirmed in 9000 year old human remains
Tuberculosis is a major global cause of death and disease, with around one third of the world’s population believed to be infected with the M. Tuberculosis bacterium. Tuberculosis is known to have infected mankind since ancient times, and a new…
