Huntington’s disease is an inherited neurodegenerative disorder associated with mutations in the huntingtin gene on human chromosome 4. Although the functions of normal huntingtin protein are not entirely clear, it is known that abnormal huntingtin (mutantHtt, or mHtt) – and…
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Faulty ‘Garbage Disposal’ in Huntington’s Disease
Huntington’s disease (HD) is a genetic disorder caused by mutations in the huntingtin gene. The altered huntingtin protein (htt) causes gradual neurological damage; HD usually develops between the ages of 30 and 50 and symptoms get worse over the next…
Promise on the Horizon for Huntington’s
Results from a phase II trial of the experimental drug Dimebon (latrepirdine) in people with Huntington’s disease have provided indications that it may improve cognition. The drug, being developed by Medivation, Inc., is also in Phase III trials for Alzheimer’s…
Rhes Protein Linked to Cell Death in Huntington’s Disease
Huntington’s disease (HD) is an inherited neurological disorder that causes a wide range of symptoms including involuntary movements, clumsiness, lack of concentration, memory lapses, mood swings, and depression. Although the disease mechanism is not fully understood, it is known that…
IKKβ Linked to Huntington’s Disease
The neurodegenerative disorder, Huntington’s Disease (HD, Huntington’s Chorea), is caused by mutations in the gene for the protein Huntingtin (Htt). Mutant Htt (mHtt) results when the number of trinucleotide repeats, in this case the CAG sequence encoding glutamine, exceeds a…
Huntington’s Drug Approved in US
Huntington’s Disease is a hereditary neurological disorder caused by a fault in the gene that produces a protein called Huntingtin. The function of Huntingtin is not clear, but the presence of abnormal protein increases the rate of neuronal cell death…
