Comments on: Syk Protective Against Breast Cancer http://drugdiscoveryopinion.com/2009/10/syk-protective-against-breast-cancer/ DDO Limited - Consultancy for Biotech and Pharma Fri, 11 May 2012 17:42:28 +0000 hourly 1 http://wordpress.org/?v= By: Breast Cancer Conquer http://drugdiscoveryopinion.com/2009/10/syk-protective-against-breast-cancer/comment-page-1/#comment-1416 Breast Cancer Conquer Sun, 20 Dec 2009 16:51:04 +0000 http://drugdiscoveryopinion.com/?p=1789#comment-1416 I just read about a new targeted cancer drug that has been shown to shrink tumors in women with metastatic breast cancer after an average of seven other drugs, including Herceptin, failed. The new drug, called T-DM1, combines Herceptin with a potent chemotherapy drug. Here's to keeping our hopes alive that someday this retched disease can be nothing but a memory! One word comes to mind when it comes to breast cancer conquer. Happy Holidays to All! I just read about a new targeted cancer drug that has been shown to shrink tumors in women with metastatic breast cancer after an average of seven other drugs, including Herceptin, failed. The new drug, called T-DM1, combines Herceptin with a potent chemotherapy drug. Here’s to keeping our hopes alive that someday this retched disease can be nothing but a memory! One word comes to mind when it comes to breast cancer conquer. Happy Holidays to All!

]]> By: Umesh http://drugdiscoveryopinion.com/2009/10/syk-protective-against-breast-cancer/comment-page-1/#comment-876 Umesh Mon, 19 Oct 2009 12:13:23 +0000 http://drugdiscoveryopinion.com/?p=1789#comment-876 I am not well versed (as I am a synthetic organic chemist and interested in understanding about the antisense drugs, RNAis & other nucleic acid derivatives) with mode of action, I found this paper interesting and I am copying here the summary of the paper for your reference pls. do comment... "Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable of accelerating lymphomagenesis in a well-characterized mouse lymphoma model, we identified over ten candidate tumor suppressors, including Sfrp1, Numb, Mek1, and Angiopoietin 2. Several components of the DNA damage response machinery were also identified, including Rad17, which acts as a haploinsufficient tumor suppressor that responds to oncogenic stress and whose loss is associated with poor prognosis in human patients". Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model Scott W. Lowe et. al., Journal : http://www.sciencedirect.com I am not well versed (as I am a synthetic organic chemist and interested in understanding about the antisense drugs, RNAis & other nucleic acid derivatives) with mode of action, I found this paper interesting and I am copying here the summary of the paper for your reference pls. do comment…

“Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable of accelerating lymphomagenesis in a well-characterized mouse lymphoma model, we identified over ten candidate tumor suppressors, including Sfrp1, Numb, Mek1, and Angiopoietin 2. Several components of the DNA damage response machinery were also identified, including Rad17, which acts as a haploinsufficient tumor suppressor that responds to oncogenic stress and whose loss is associated with poor prognosis in human patients”.

Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model
Scott W. Lowe et. al.,

Journal : http://www.sciencedirect.com

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