Comments on: Enabling Safer Paracetamol

By: Magdi

Magdi — Sun, 06 Mar 2011 20:02:34 +0000

In addition to what you have suggested, it is also possible that the highly electron-withdrawing benzoisothiazol ring pulls electrons, through inductive effect, away from the nitrogen of the acetamido group leaving it unreactive to the hydroxylation reaction. The formation of NAPQI is not possible unless the N-hydroxy metabolized is formed. The later is highly electrophilic that the attack by the nucleophilic proteins readily occur.

By: WH

WH — Tue, 21 Jul 2009 16:59:55 +0000

I would guess that you are right. Although I haven’t seen any detail on the metabolism of SCP-1 or SCP-123, it may be that the improved window is due to faster clearance. There is reference to greater water solubility of the SCP-derivatives.

By: Curious Wavefunction

Curious Wavefunction — Tue, 21 Jul 2009 16:20:17 +0000

But can’t SCP 1/SCP 123 undergo the same reaction with the amide?