http://drugdiscoveryopinion.com/2009/02/gsk-3-inhibitors-help-maintain-pluripotency/ DDO Limited - Consultancy for Biotech and Pharma Fri, 11 May 2012 17:42:28 +0000 hourly 1 http://wordpress.org/?v= http://drugdiscoveryopinion.com/2009/02/gsk-3-inhibitors-help-maintain-pluripotency/comment-page-1/#comment-770 Drug Discovery Opinion » GSK-3 – Master Controller of Neural Stem Cells Wed, 07 Oct 2009 07:35:34 +0000 http://drugdiscoveryopinion.com/?p=795#comment-770 [...] Image: Flickr - KhazaeiGSK-3 (glycogen synthase kinase-3) is a serine-threonine kinase that consists of two family members in mammals, α and β, which share 98% sequence identity in their kinase domains. The β-isoform has recently been identified as a mediator of neurogenesis under the control of DISC1, a protein encoded by a gene implicated in schizophrenia susceptibility. GSK-3 has also been shown to be involved in regulation of embryonic stem cell self-renewal – GSK3 inhibitors help in maintenance of pluripotency. [...] [...] Image: Flickr – KhazaeiGSK-3 (glycogen synthase kinase-3) is a serine-threonine kinase that consists of two family members in mammals, α and β, which share 98% sequence identity in their kinase domains. The β-isoform has recently been identified as a mediator of neurogenesis under the control of DISC1, a protein encoded by a gene implicated in schizophrenia susceptibility. GSK-3 has also been shown to be involved in regulation of embryonic stem cell self-renewal – GSK3 inhibitors help in maintenance of pluripotency. [...]

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